ADDITION: Shout! Factory - Region 'A' Blu-ray - January  2016': I don't While totally inferior to Donovan's Brain that came out almost a decade before, The Brain That Wouldn't Die has it place in cinema's history (perhaps for some of the wrong reasons residing in a very schlocky place - but still.) Shout! Factory do this up right with a widescreen (1.66:1) - referred to as the uncut version version - and you can see the results as compared to the 2000 DVD - which must have been open-matte. It appears as though we lose some superfluous information off the top, a sliver off the right side but actually gain a bit on the left edge. Framing is fine in the new 1080P with a few chopped heads (no pun intended) but it's of the 'who cares?' variety even for purists. The HD transfer looks quite good - dramatically sharper, superior contrast and even some desirable depth. You can see for yourself it's really no contest.

Shout! Factory use a DTS-HD Master 2.0 channel at 1577 kbps and it sounds surprisingly strong (note the echo effect in the strippers change room - also present on the DVD). So it's, presumably accurate in the lossless with effects rely on the theme music entitled 'The Web' by Abe Baker and Tony Restaino. It may be imperfect - thanks to the production limitations - but its sounds a heck of a lot cleaner and tighter than the SD. There are optional subtitles - in a small, gaudy, yellow font (see sample).

Extras are very appealing with an enjoyable audio commentary with film historian and author Steve Haberman and writer Tony Sasso filled with background information and interesting data. Also included the the Mystery Science Theater 3000 episode of “The Brain That Wouldn’t Die” in Standard Definition running over 1.5 hours. I was never a fan of these but I did watch quite a bit of it and had a few chuckles. There is an alternate scene from the International Cut with plenty of nudity (Miss Marilyn Hanold looking very buff), a theatrical trailer and still gallery.