The eponymous MR. & MRS. MURDER are ToxiClean forensic cleaning couple Charlie Buchanan (Austalian TV personality Shaun Micallef, who also co-created the series) and his wife Nicola (Kat Stewart, MACBETH) in this Australian screwball comic mystery series. With the help of Nicola's long-suffering niece Jess (Lucy Honigman), the Buchanans apply their particular brands of observation and tenacity to cases while letting impossibly thick detective Peter Vinetti (Jonny Pasvolsky, MORTDECAI) take credit in exchange for referrals. In "Early Checkout", the Buchanans book a room at a swanky Melbourne hotel after cleaning up the mess left after the killing of a motivational speaker. The main suspect (Hugo Johnstone-Burt, MISS FISHER'S MURDER MYSTERIES) was found covered in blood with a knife in his hands, but Nicola sets her eyes on the victim's wheelchair-bound business manager (Belinda Bromilow, NOT SUITABLE FOR CHILDREN) while Jess poses as a temporary maid. It's "A Dog's Life" when a golf club owner (TV presenter Merrick Watts) is torn apart by a vicious dog after clashing with local dog owners trespassing on the greens. Charlie discovers which vicious dog served as the weapon but does not believe its violent ex-con owner (Jack Finsterer, KOKODA: 39TH BATALLION) "pulled the trigger." Murder is "En Vogue" when a cut-throat fashion designer (Henry Nixon, TRIANGLE) meets a demise on the catwalk that is "part Shakespeare, part Road Runner cartoon." When an immigrant body building contestant is found "cooked" to death in a tanning bed in "Atlas Drugged", the Buchanans look beyond his fellow competitors to the contest promoter (Vince Colosimo, THE GREAT GATSBY) and his own favorite contender (Dwayne Cameron, THE LOCALS).

When the star of the Amy Winehouse musical "Lost Soul" is found murdered, the Buchanan's tread the boards to identify her killer among the superstitious and temperamental cast and crew. Vinetti is off the case when "The Next Best Man" is murdered before the wedding of his ex-wife's (Vanessa Gray, BAD KARMA) little sister (Amber Clayton, ST. VINCENT). Vinetti would like to think the likely killer was the dead man's stalker ex-girlfriend, but things become considerably more complex when Charlie and Nicola discover that the aged patriarch (Bob Ruggiero, GHOST SHIP) was about to hand over th family business to the victim. In "Thoroughly Dead Thoroughbred", Jess adopts an Irish accent to snoop at a prestigious stable after its resident vet is given an overdose of Ketamine. While the Buchanans discover some compelling ties to the illicit drug trade, the vet's death may have something to do with a growing pattern that suggests a "serial killer of horses." When a returning solo "around the world" (Georgia Chara) sailor is brutally murdered, her possessive father (Robert Taylor, LONGMIRE) is too hung over to offer an alibi. Charlie and Nicola, however, focus on a more intriguing list of suspects including the victim's wicked stepmother (Kellie-Michelle Cheung), controlling ex-boyfriend (Nikolai Nikolaeff), his insecure new flame (Jessica Tovey, LEMON TREE PASSAGE), and the dead girl's middle-aged secret lover (Frank Magree, NED KELLY).

When the body of a homeless man is discovered in a chic gallery hosting the Audacity of Art competition, a seeming break-in turns out to be "The Art of Murder" and one of the suspects trying to make a grisly artistic statement and the gallery owner (Helen Thomson, KANGAROO JACK) has plenty to hide. When the body of an IT mogul is found impaled on a spear in one of Melbourne Beach's "Little Boxes", the Buchanans uncover the embarrassing secrets in ex-Olympian/stock market genius Richard Naylor's (Martin Lynes, HOME AND AWAY) family including illicit affairs, lawsuits, and an artifact from Australian nautical history. Nicola goes under the knife in "Keeping Up Appearances" when a wealthy woman with body dysmorphia is found dead beneath the window of a prominent plastic surgeon (Nicholas Brown). The case starts looking less like a dramatic suicide when the Buchanans delve into the victim's private life and find inconsistences, including a sister (Ella Scott Lynch, SHINE) who stands to inherit an entire family fortune. When a big cat keeper is found bludgeoned to death in "Zootopia", the Buchanans suspect that his conveniently-vanished hippo-keeper ex-girlfriend is either the killer or another victim. The Buchanans become foodies in "The Course Whisperer" when a famous chef is murdered in his own kitchen and his body mysteriously spirited away.

"Grey is the new black" in MR. & MRS. MURDER, and our detectives find in more than a few cases that their villains (or even those suspects who turn out to be guilty of lesser transgressions) are not always the ruthless master villains, although there certainly are a few that threaten their lives (and one Hannibal Lecter-esque baddie who seems to be set up for a return, although there does not seem to have been a second series). While most sleuthing couples of late tend to favor the smart and impulsive wife and blundering and oblivious husband dynamic, Nicola is indeed impulsive but also observant and sensitive to body language and emotions while Charlie is more reserved but also extremely observant, knowledgeable, deductive, and is able to test out and explain his deductions compared to his wife's "I can feel it in my waters" hunches. Micaleff and Stewart have an easy chemistry even if some of their pop culture banter feels forced (they share a passion for BLADE RUNNER - the "version without all the narration" - and their first date movie was VANILLA SKY). Book club friends Alan (Ben Geurens, BODY MELT), a wheelchair-bound former spy, and "Menopause the Musical" Janine (Georgina Naidu) provide, respectively, consultancy and diversion.