Since their parents ran out on them under the pretense of taking a brief vacation to Florida, Amy Bear (Krysten Ritter, 27 DRESSES) gave up her college and career ambitions to take care of her brother Nat (Logan Huffman, COMPLICITY) - who is having trouble with social interaction following neurological complications from the removal of a brain tumor - and sister Lucy (Madeleine Martin, TV's CALIFORNICATION) who has taken to drugs and delinquency in addition to being a moody teenager. Amy loses herself in books - most recently, Paul Bowles' The Sheltering Sky - and has one night stands whenever she craves intimacy. Her latest pickup is Sam (Brian Geraghty, THE HURT LOCKER) who has been drifting aimlessly since he killed his brother in a drunk-driving crash. He proposes renting a room in Amy's house, and his initially unsettling presence soon lifts Amy's spirits but also provides a sense of normalcy to the household. When Sam disappears for a few days, Amy realizes how much she wants and needs Sam. When he returns and proposes to her, however, she starts to yearn for who she could be or could have been without the familial baggage Sam is eager to embrace. Fearing that Amy might abandon them as well, Lucy and Nat - who has formed a friendship with Born Again shopkeeper Gary (Chris Papavasiliou, DETACHMENT) conspire to get rid of Sam who might be the only person capable of giving Amy a reason not to run (or at least retreat) that doesn't involve familial obligation and guilt.