Architect Federica (Margherita Buy, DAYS AND CLOUDS) and former actress-turned-diet restaurateur Marina (Sabrina Ferilli, SWEETS FROM A STRANGER) have been together for five years, and are just about to experience what Marina describes as happening to all couples after five or six years. Still closeted to all but her family and her partner, Federica still feels guilt for the effect of leaving her husband Stefano (Massimiliano Gallo, LOOSE CANONS) on her now twenty-year-old son Bernardo (Domenico Diele) when he fails to keep her abreast of his busy love life. When Marina does an interview for a magazine that touches upon her sexuality and she mentions that she is in a relationship with an architect, Federica finds herself in the uncomfortable position of being "outed" to the public. When a young filmmaker flatters Marina with the offer of a small but prominent role in his new comedy, Federica's ends up insulting Marina as she tries to discourage her out of concern for the extra attention the publicity might put on their relationship. After running into optometrist Marco (Fausto Maria Sciarappa, THE GIRL BY THE LAKE), a man from her past with whom she had shared a mutual unacknowledged attraction, Federica starts to question her choices and enters in an illicit affair with him. When Marina catches them, she tries to be rational and offers to forget the matter if Federica ends the affair, but Federica finds her unexplored feelings and the lingering question of whether she is really a "full-fledged lesbian" gnawing at her conscience and threatening the happiness she knows that she has with Marina. Despite the central emotional dilemma, ME, MYSELF & HER - destined to share shelf space with the awful ME, MYSELF & IRENE by virtue of its English title (the Italian title is simply IO E LEI and was possibly changed to discourage confusion with Bernardo Bertolucci's IO E TE) - is a rather light comedy from Maria Sole Tognazzi (daughter of actor Ugo Tognazzi and actress Franca Bettoia).