http://cancer-is-metabolic.health

Metabolic - relating to or deriving from the metabolism of a living organism.

Metabolism is the chemical reactions in the body's cells that change food into energy. Our bodies need this energy to do everything from moving to thinking to growing. Specific proteins in the body control the chemical reactions of metabolism.

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My name is Gary. I am not a Doctor and I hope I have not misused some medical terminology below. This webpage mostly cites the work of Dr. Thomas Seyfried, professor of biology, genetics, and biochemistry at Boston College, who has over 150 peer-reviewed publications. It follows the pivotal work of Dr. Otto Warburg (1883 - 1970) "The Nobel laureate Otto Warburg―a cousin of the famous finance Warburgs―is widely regarded as one of the most important biochemists of the twentieth century." Dr. Jason Fung is in the close vicinity of these theories with a focus on genetics, and that cancer is caused by the dysregulation of insulin. Also Dr. Peter Attia, HERE from 2014.

They have all written a number of books regarding Cancer being classified as a metabolic disease.

 

Dr. Jason Fung:
The Cancer Code: A Revolutionary New Understanding of a Medical Mystery

Dr. Thomas Seyfried:
Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer

Keto for Cancer: Ketogenic Metabolic Therapy as a Targeted Nutritional Strategy

Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer. Student Edition

Dr. Otto Warburg:

Dr. Otto Warburg’s Cancer Research Papers (Understand Cancer Series Book 6)


Cancer Facts

• Currently it is the number two killer after heart disease and within 5-years will probably be moving to number 1. 
As a North American you are MORE likely to get Cancer in your lifetime than to avoid it.
• 1700 people, each day, in the United States die of Cancer (5,000 / day in China.) "Imagine if this was Ebola".

50% of people who die of Cancer - die of the treatment.
• The species closest link to us is the Chimpanzee. There has never been a female Chimp caught in the wild with breast Cancer.
• Breast Cancer has overtaken heart disease as the number one cause of death in women over 40-years of age in the United States.
• Albert Schweitzer (1912) traveled in Africa and lived with 40,000 natives. He knew what Cancer was... and could not find any in the native population.
• Cancer has, largely, remained incurable (treatments that kill cancer cells while leaving the surrounding normal cells intact.)
• Cancer is a trillion dollar industry.

Cancer is a substrate of modern lifestyle - most notably diet. You can inherit (genetic) Cancer but it is never 100%. It is highly probable that you are influenced to adapt the lifestyle and diet of your parents. You can contract cancer by being exposed to carcinogenic material (provocative agents ex. asbestos, trace radiation, Round-Up etc.) but it is not 100% or getting a virus (HPV - Human papillomaviruses, Epstein-Barr etc.) but it is not 100%. You can have a diet rich in carcinogens (ex. ultra-processed foods and drinks etc.) but, still, not always contract Cancer (although your odds may increase.) 

 

What is the common pathophysiological mechanism that always happens to produce Cancer?

 

Cancer cells elicit from the cells inability to produce oxygen. They replace Oxidative phosphorylation with a fermentation metabolism. Anaerobiosis (Warburg) - they live without oxygen.

All Cancers are, essentially, exactly the same in that they have one thing in common; how they obtain energy to flourish. Cancer cells thrive in hypoxic (oxygen insufficient) conditions making treatment problematic. 

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Here are some notes - this is NOT that hard to understand (there are YouTube videos at the bottom) You need to learn about evolutionary biology to understand how Cancer works and how to control it.

 

(Edward Judd and Peter Cushing in 1966's Island of Terror)
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Cancer cells grow in your body. The treatment goal is to stop the growth and/or kill the cancer cells.

There are currently three mainstream methods of treating Cancer. There have been no significant advances beyond them in 80 years.
1) Surgery - cut out the Cancer from the body
2) Poison the Cancer cells - Chemotherapy
3) Irradiate (burn them) the malignant Cancer cells to kill or control their growth
Or various combinations of these three.
The last two involve, hopefully, eradicating the Cancer cells before the treatment kills the patient.
All three medical treatments come with dangers - and are costly.... and profitable.

Nobel Prize winner Otto Warburg (Science, 24 February, 1956)
Warburg Theory of Cancer
1. Cancer arises from damage to cellular respiration.
2. Energy through fermentation gradually compensates for insufficient respiration.
3. Cancer cells continue to ferment lactate in the presence of oxygen (Warburg effect).
4. Enhanced fermentation is the signature metabolic malady of ALL cancer cells.

Cancer is widely considered a genetic disease (as stated on the Cancer Society website) involving "nuclear mutations in oncogenes and tumor suppressor genes". This view persists despite the numerous inconsistencies associated with the somatic mutation theory that "cancer begins with a genetic change in a single cell that passes it on to its progeny, thereby generating a clone of malignant cells." No - this idea is antiquated. 

In contrast to the somatic mutation theory, emerging evidence suggests that cancer is a mitochondrial metabolic disease, according to the original theory of Otto Warburg (Nobel Prize 1931, nominated 26 times.) The findings are reviewed from nuclear cytoplasm transfer experiments that relate to the origin of cancer. The evidence from these experiments is difficult to reconcile with the somatic mutation theory, but is consistent with the notion that cancer is primarily a mitochondrial metabolic disease.

Oxidative phosphorylation is a cellular process that harnesses the reduction of oxygen to generate high-energy phosphate bonds in the form of adenosine triphosphate (ATP) which promotes tumour progression.

Conclusions
1. Cancer is a type of mitochondrial metabolic disease: It is not a genetic disease! Genetics are downstream - even if you have BRCA1 or BRCA2 gene - inherited from either parent - your odds of Cancer are, roughly, 50%. Meaning 50% do NOT get it.
2. The restriction of glucose can manage all types of cancer.

"Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar." — Otto H. Warburg

While genes are not 100% predictive - all Cancers have the exact same growth process; fermentation. This is 100%. These are considered 'ancient pathways' because it is how single cell growth happened over 2.5 billion years ago before we had oxygen.

Great Oxygenation Event (GOE), is the period beginning of oxygen's permanent presence in the atmosphere, started as early as 2.33 billion years ago.

Brain, lung, cervix, breast, organ etc. Cancers have one thing in common. The cells derive their energy from fermentation (NOT oxygen) of Glucose and Glutamine. 100% of all cancers grow through dysregulation of your Mitochondria. If you have healthy mitochondria your body will not allow an environment for Cancer cells to grow. This could be called keeping your body in "metabolic homeostasis."

Glutamine is the most abundant amino acid found in the body. It's made in the muscles and transferred by the blood into different organ systems. Glutamine is a building block for making proteins in the body. 

Glucose is overall the most abundant monosaccharide, a subcategory of carbohydrates.

Warburg hypothesized that cancer growth is caused by tumor cells generating energy (as, e.g., adenosine triphosphate/ATP) mainly by anaerobic breakdown of glucose (known as fermentation, or anaerobic respiration). This is in contrast to healthy cells, which generate energy mainly from oxidative breakdown of pyruvate. Pyruvate is an end product of glycolysis and is oxidized within the mitochondria. Hence, according to Warburg, cancer should be interpreted as a mitochondrial dysfunction.

Nearly a century ago, Otto Warburg discovered that tumours consume tremendous amounts of glucose relative to most non-transformed tissues, and that the majority of glucose consumed by tumours is fermented to lactate, rather than oxidized in pathways that require respiration.

A positron emission tomography (PET) scan is an imaging test where glucose is being used in the body. Cancer cells show up brighter in the picture because they are more active and take up more glucose than normal cells do.

BOTTOM LINES:
 

Given that its primary driver is a metabolic component Cancer is amenable to simple, low-cost treatments. These can be affected through diet and lifestyle change without costly, invasive and/or poisonous alternatives. The Warburg hypothesis states that cancer cells have an altered cell metabolism towards anaerobic glycolysis. Given this metabolic reprogramming in cancer cells, it is possible to target cancers metabolically by depriving them of their required energy component; glucose.

Concentrate on Cancer prevention. Number one factor is type II diabetes (which is reversible) and number two is obesity. Not only are both factors conjoined but they are more likely to contract cancer, and also to have poor Cancer outcomes. It is no coincidence that the Warburg / Attia / Seyfried / Fung treatment for Cancer is the same as the prevention; produce ketones by eating less carby processed foods (how about 'none'? including zero sugar) and adapt a regime of intermittent fasting.

• It is now known that 'water-only fasting' for 72 hours reduces tumour growth - shrinks Cancer tumours.
• It is difficult to FAST effectively if your primary energy is carbohydrates or, its stored form, glycogen ("If you get into a fight with your hypothalamus, you will lose every time")
• It will become significantly easier if your blood ketone level is above 0.5 (meaning you are producing some level of nutrional fat burning ketones) Reduce your carbohydrates significantly over time (2-6 weeks - but don't overindulge in protein.) Eating animal fat satiates diets.
• Keep your cells oxygenated - exercise, breathe fresh air etc.
• Cancer evolves from dysregulation of your mitochondria (and dysregulation of insulin - Fung)
All Cancer cells grow through fermentation and require Glucose + Glutamine. Period. Prevent this process from transpiring.
• Ketones are the 'super food' for your mitochondria. Make your body a factory to produce them... as your ancestors.
• You produce ketones by avoiding ingestion of carbohydrates and/or fasting.... similar to the human diet when your body was designed a millennia ago.
Fasting is free and anyone can do it. There is no profiting middle-man. No agenda. No special pills. No adverse side effects if done properly.
• You can live your entire life with very minimal carbohydrates - eating instead; meat, eggs, seafood, even dairy (for most) as your body requires.
• Your primary energy source will change from using carbohydrates to using fat (think of it as "Regular" gasoline to "Premium"). You can then go long time-frames without eating, needing to, or feeling hungry. Just like your ancestors.
• You are essentially starving the cancer of its energy source - the required glucose - while improving, and actually increasing (Chafee et all,) your mitochondria. Cancer only survives and propagates in a disregulated mitochondria.
•  None of this means that Chemo, surgery etc. aren't effective. Fasting should be used as an important option ("Informed consent") or adjunct for existing Cancer treatment. There are 10s of 1000s of Cancer patients documented surviving even stage 4 brain and lung Cancers using fasting therapy (see Cancer Evolution movie below). It should be an option... because it works.

Dr. Thomas Seyfried - "Cancer is a metabolic disease"

 


 

 


 

 

 

 

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Somewhere in this video Attia and Seyfried argue about biopsies transferring Cancer cells:

 

 

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At 8-minutes Seyfried states the theory that biopsies transfer Cancer cells.

 

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At 40:00 minutes, in this video, in Dr. Thomas Seyfried mentions the anti-parasitic mebendazole (a worm parasite) and that it also targets the metabolism in the tumor cells - so the parasite and the Cancer cell use a common form of energy. You can buy it in India for $0.50 a tablet:

 

At 36:00 minutes, in this video, in Dr. Thomas Seyfried again discusses the anti-parasitics fenbendazole (HERE are Fenbendazole Cancer Success Stories. A NLM study HERE) and mebendazole:

 

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At 1:01:30 minutes, in this video, in Dr. Thomas Seyfried again discusses the anti-parasitics mebendazole "Parasite medication - use fermentation metabolism to stay alive, blocks glucose and glutamine (mild inhibitor)":

 

Seyfried briefly on Mebendazole and Fenbendazole (3:00)

 

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Dr. Jason Fung + Dr. Berry Cancer Code
 


 

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Colin Champ, MD -- The Ketogenic Diet and Cancer

 

Data from over 100 years ago:

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Cancer Evolution
https://cancerevolution.film


 

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How to gauge your maximum prevention ability and most effective treatment level of Cancer, using a KetoMojo meter (GKI):

 

There are a variety of both Ketone measuring devices (use blood levels not "urine sticks") and Glucose measuring instruments but the KetMojo does both self-identifying the strip when put into it.

 

 

Dr. Ekberg discusses GKI at 37-minutes in this video

  GKI guage
≥9 You have not reached ketosis yet.
6-9 You’re in a low level of ketosis. Ideal for anyone whose goal is weight loss or maintaining optimal health.
3-6 You’re in a moderate level of ketosis. Ideal for those with type 2 diabetes, obesity or insulin resistance.
≤3 You’re in a high therapeutic level of ketosis. Ideal for patients who have cancer, epilepsy, Alzheimer’s disease, Parkinson’s disease.
Below 2.0 you are in a state of metabolic homeostasis.

[Blood Glucose Result ÷ 18] ÷ Blood Ketone Result = GKI
 

By dividing the blood glucose result by 18, it converts the reading from milligrams (mg) per deciliter (dL) to millimoles per litre. Example:

 

Glucose:

97 millimoles per litre divided by 18 = 5.4 milligrams (mg) per deciliter (dL)

divided by your

Ketone level

2.2 millimoles per litre

= 2.4 GKI (Glucose Ketone Index)

05/08/24 - 5.2 / 3.6 = 1.45 GKI (middle of 90-hour fast)

08/08/2024 - 6.0 / 2.4 = 2.5 GKI (was eating)

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Definitions:

 

Metabolic homeostasis - processes include those normal functioning of the break down nutrients from our food, and those that build and repair our body.

Oxidative phosphorylation: the metabolic pathway in which cells use enzymes to oxidize nutrients. The process of turning glucose and fatty acid into lots of ATP using oxygen is called ‘oxidative phosphorylation.’

Adenosine Triphosphate (ATP): is a nucleotide that provides energy to drive and support many processes in living cells, such as muscle contraction, nerve impulse propagation, and chemical synthesis. "The currency of energy."

The Warburg Effect: the observation that all cancers use aerobic glycolysis (fermentation) for energy generation rather than the mechanisms used by non-cancerous cells (Oxidative phosphorylation). NOTE: "Cancer cells “prefer” to use the energetically highly inefficient method of burning the glucose at the cellular level." If oxygen is present Cancer Cells should stop using inefficient fermentation. They don't. They can't.

Warburg’s hypothesis for cancer progression is that cancer cells undergo a two-step transformation. First, there is irreversible failure of respiration, and secondly, the cell survives by fermentation energy. Fermentation energy is far less efficient than aerobic glycolysis, producing only 2 ATP for a glucose molecule as opposed to 38 via aerobic glycolysis.

Aerobic Glycolysis or Aerobic fermentation: metabolic process by which cells metabolize sugars via fermentation in the presence of oxygen and occurs through the repression of normal respiratory metabolism.

A positron emission tomography (PET): In PET, a small amount of radioactive glucose is injected into a vein, and a scanner makes a picture of where the glucose is being used in the body.

Somatic mutation theories postulate that the origin of diversity is a normal genetic event (mutation, deletion, insertion or recombination) which occurs in V genes at low frequency throughout the life of the individual. (this is strikethrough'ed to indicate it is an incorrect theory.)

Mitochondria are membrane-bound cell organelles (mitochondrion, singular) that generate most of the chemical energy needed to power the cell's biochemical reactions. Chemical energy produced by the mitochondria is stored in a small molecule called adenosine triphosphate (ATP).

Reactive Oxygen Species: ROS have roles in cell signaling and homeostasis. ROS are intrinsic to cellular functioning, and are present at low and stationary levels in normal cells. In plants, ROS are involved in metabolic processes related to photoprotection and tolerance to various types of stress. ROS are carcinogenic and mutagenic.

Intravasation of tumor cells into the circulation can occur through entry into blood vessels or lymphatic vessels, with the majority of entry occurring through hematogenous (blood vessel) routes.

Extravasation is both a process and a medical condition: Extravasation is the multistep process cells use to move from your bloodstream into your tissues. Extravasation is the condition that may happen if fluids spill from IV (intravenous) lines during chemotherapy treatment.

"The Cancer cell is constantly hovering near death because of the difficult path it must go to obtain energy."

"It's all about the mitochondria"

"Cancer cells can't burn Ketones or fatty acids - because they cannot be fermented."

"Nutritional Ketosis prevents chronic diseases"

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Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. Cancer is suppressed following transfer of the nucleus from the tumor cell to cytoplasm of normal cells containing normal mitochondria. These findings indicate that nuclear genetic abnormalities cannot be responsible for cancer despite commonly held beliefs in the cancer field. The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular energy metabolism. The disturbances in tumor cell energy metabolism can be linked to abnormalities in the structure and function of the mitochondria. Cancer growth and progression can be managed following a whole-body transition from fermentable metabolites, primarily glucose and glutamine, to respiratory metabolites, primarily ketone bodies. This transition will reduce tumor vascularity and inflammation while enhancing tumor cell death. A novel “press-pulse” therapeutic strategy is in development for the non-toxic metabolic management of cancer. Malignant brain cancer in preclinical models and humans will be used to illustrate general concepts. As each individual is a unique metabolic entity, personalization of metabolic therapy as a broadbased cancer treatment strategy will require fine-tuning to match the therapy to an individual’s unique physiology.

Thomas N. Seyfried received his Ph.D. in Genetics and Biochemistry from the University of Illinois, Urbana, in 1976. He did his undergraduate work at the University of New England, where he recently received the distinguished Alumni Achievement Award. He also holds a Master’s degree in Genetics from Illinois State University. Thomas Seyfried served with distinction in the United States Army’s First Cavalry Division during the Vietnam War and received numerous medals and commendations. He was a Postdoctoral Fellow in the Department of Neurology at the Yale University School of Medicine and then served on the faculty as an Assistant Professor in Neurology. Other awards and honors have come from such diverse organizations as the American Oil Chemists Society, the National Institutes of Health, The American Society for Neurochemistry, and the Ketogenic Diet Special Interest Group of the American Epilepsy Society. Dr. Seyfried previously served as Chair, Scientific Advisory Committee for the National Tay-Sachs and Allied Diseases Association and presently serves on several editorial boards, including those for Nutrition & Metabolism, Neurochemical Research, the Journal of Lipid Research, and ASN Neuro, where he is a Senior Editor. Dr. Seyfried has over 150 peer-reviewed publications and is the author of the book “Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley Press).”

Subsidiary:

Ketogenic diet as a metabolic vehicle for enhancing the therapeutic efficacy of mebendazole - pediatric glioma

 

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